Trimethylamine N oxide (TMAO) is a small molecule produced in humans primarily by the gut liver axis and has become an important biomarker, and possible mediator, of cardiometabolic and renal disease. Dietary choline, phosphatidylcholine ( The Microbial Metabolite Trimethylamine N Oxide Links Vascular Dysfunctions and the Autoimmune Disease Rheumatoid Arthritis TMAO metaorganismal pathway and chronic inflammatory diseases Nutrition Dark Matter and Impact on Health Dr. Leonardo Riella Trimethylamine N Oxide (TMAO) as a Biomarker Springer Nature Link The anti atherogenic bioactive metabolites of natural medicine generated by host microbe co metabolism system. The terminal metabolites of low bioavailable polysaccharides are SCFAs, among which propionate and butyrate can effectively attenuate